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Gaboxadol hydrochloride

Product NameGaboxadol hydrochloride
CAS85118-33-8
MFC6H9ClN2O2
MW176.6
EINECS285-687-7
MOL File85118-33-8.mol

Chemical Properties

Melting point	236 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	ethanol: soluble0.91mg/mL
form	solid
color	white
Merck	14,4321
InChI	1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
InChIKey	ZDZDSZQYRBZPNN-UHFFFAOYSA-N
SMILES	Cl[H].Oc1noc2CNCCc12

Safety Information

Safety Statements	22-24/25
WGK Germany	3
RTECS	NY3396800
HS Code	2934.99.9001
Storage Class	11 - Combustible Solids

Usage And Synthesis

Uses

As a molecular probe to study GABA receptors.

Uses

GABAergic Agonist

Uses

Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.

Uses

Gaboxadol is a sleep aid drug used for the treatment of chronic pain and insomnia. Gaboxadol is also known to exhibit antidepressant like properties through its agonistic activities towards GABA sites .

General Description

Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.

Biochem/physiol Actions

GABAA receptor agonist.

in vivo

Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by Fmr1 KO2 mice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity in Fmr1 KO2 mice^[2].

Animal Model:	Fmr1KO2 mice (deletion of the promoter and first exon ofFmr1resulting in mRNA and protein null mice)^[2]
Dosage:	0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg
Administration:	Intraperitoneal injection
Result:	Normalized Hyperactivity Observed inFmr1KO2 mice.

storage

Store at RT

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