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GABOXADOL HYDROCHLORIDE Basic information
Product Name: GABOXADOL HYDROCHLORIDE
Synonyms: 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate;4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride;THIP HYDROCHLORIDE (GABOXADOL) POST-SYNA PTIC GABA RE;THIP hydrochloride, 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride;Einecs 285-687-7;Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, Monohydrochloride;Gaboxadol hydrochloride solid, >=98% (HPLC);4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt)
CAS: 85118-33-8
MF: C6H9ClN2O2
MW: 176.6
EINECS: 285-687-7
Product Categories:
Mol File: 85118-33-8.mol
GABOXADOL HYDROCHLORIDE Structure
GABOXADOL HYDROCHLORIDE Chemical Properties
Melting point 236 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility ethanol: soluble0.91mg/mL
form solid
color white
Merck 14,4321
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS NY3396800
HS Code 2934.99.9001
MSDS Information
GABOXADOL HYDROCHLORIDE Usage And Synthesis
Uses GABAergic Agonist
Uses Gaboxadol is a sleep aid drug used for the treatment of chronic pain and insomnia. Gaboxadol is also known to exhibit antidepressant like properties through its agonistic activities towards GABA sites .
Uses As a molecular probe to study GABA receptors.
Uses Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.
General Description Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.
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