2-Amino-5,7-dimethoxy-1,2,4-triazolo[1,5-a]pyrimidine

102739-44-6

13223-43-3

The general procedure for the synthesis of 2-amino-5,7-dimethoxy-1,2,4-triazino[1,5-a]pyrimidine from the compound (CAS:102739-44-6) was as follows: 3a (114.5 g, 0.4 mol) and hydroxylamine hydrochloride (40.3 g, 0.58 mol) were dissolved in ethanol (600 mL) and stirred vigorously at 60 °C for 0.5 hours. Subsequently, triethylamine (58.7 g, 0.58 mol) was slowly added dropwise to the reaction mixture. The resulting mixture was refluxed for 5 h. After completion of the reaction, it was cooled to room temperature. The white solid of product 4a was collected by filtration and washed with 200 mL of water to give 71.4 g of product in 91.5% yield.