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Suplatast tosilate

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Suplatast tosilate Basic information
Suplatast tosilate Chemical Properties
  • Melting point:84-87°C
  • storage temp. Store at RT
  • solubility DMSO: >20mg/mL
  • form powder
  • color white to off-white
  • Merck 14,9003
  • CAS DataBase Reference94055-76-2(CAS DataBase Reference)
Safety Information
  • WGK Germany 3
  • RTECS WR7906000
  • ToxicityLD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita)
Suplatast tosilate Usage And Synthesis
  • DescriptionSuplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.
  • OriginatorTaiho (Japan)
  • UsesSuplatast Tosylate is an antiallergic drug. Suplatast Tosylate inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation. Suplatast Tosylate suppresses interleukin (IL)-4 release from T cells, however in human peripheral basophils, Suplatast Tosylate inhibited the antigen-induced release of IL-13 but not IL-4.
  • UsesSuplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
  • brand nameIPD
  • Biological ActivityTh2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
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