Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  API >  Respiratory Drugs >  Asthma drugs >  Suplatast tosilate

Suplatast tosilate

Basic information Safety Related Supplier
Suplatast tosilate Basic information
Suplatast tosilate Chemical Properties
  • Melting point:84-87°C
  • storage temp. Store at RT
  • solubility DMSO: >20mg/mL
  • form powder
  • color white to off-white
  • Merck 14,9003
  • CAS DataBase Reference94055-76-2(CAS DataBase Reference)
Safety Information
  • WGK Germany 3
  • RTECS WR7906000
  • ToxicityLD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita)
Suplatast tosilate Usage And Synthesis
  • DescriptionSuplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.
  • OriginatorTaiho (Japan)
  • UsesSuplatast Tosylate is an antiallergic drug. Suplatast Tosylate inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation. Suplatast Tosylate suppresses interleukin (IL)-4 release from T cells, however in human peripheral basophils, Suplatast Tosylate inhibited the antigen-induced release of IL-13 but not IL-4.
  • UsesSuplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
  • brand nameIPD
  • Biological ActivityTh2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
Suplatast tosilate(94055-76-2)Related Product Information
Suplatast tosilateSupplierMore
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Tel:400-660-8290 21-61259100-
  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
  • Tel:18930552037 821-50328103-801
  • Company Name:Chembest Research Laboratories Limited
  • Tel:021-20908456-
  • Company Name:TCI (Shanghai) Development Co., Ltd.
  • Tel:021-67121386 / 800-988-0390