新霉素标液
新霉素标液 性质
| 熔点 | >194°C (dec.) |
|---|---|
| 沸点 | 658.4°C (rough estimate) |
| 密度 | 1.3548 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于酸性水溶液（轻微）、水（轻微） |
| 形态 | 液体 |
| 酸度系数(pKa) | 12.93±0.70(Predicted) |
| 颜色 | 透明的 |
| 生物来源 | Streptomyces fradiae |
| Merck | 13,6482 |
| 稳定性 | 吸湿性 |
| InChIKey | PGBHMTALBVVCIT-VCIWKGPPSA-N |
| SMILES | NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)[C@H](N)[C@@H](O)[C@@H]1O |
新霉素标液 用途与合成方法
Ki: 35 μM (RNase P cleavage activity) and 13.5 μM (hammerhead ribozyme)
The inhibition of RNase P RNA cleavage by Framycetin (Neomycin B; Fradiomycin B) is sensitive to pH and an increase in pH suppresses the inhibition in other systems.
Framycetin targets the bacterial and human ribosome and affect translation. 5″-azido neomycin B and Framycetin selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell line.
Framycetin binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function.
Framycetin induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site is the 16 S rRNA 1400 to 1500 region.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 42/43-63-36/37/38 |
| 安全说明 | 26-36/37/39-45-36/37-23 |
| WGK Germany | 2 |
| F | 8 |
| 存储类别 | 10 - 可燃性液体 |
| 危险性类别 | 呼吸道致敏物 类别1 皮肤致敏物 类别1 |
新霉素标液 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-17624 | 新霉素标液 | 119-04-0 | 25 mg (16.27 mM * 2.5 mL in 0.9% NaCl) | 500 |
| 2026-09-15 | HY-17624 | 新霉素标液 | 119-04-0 | 50 mg (16.27 mM * 5 mL in 0.9% NaCl) | 800 |
