Octyl gallate

111-87-5

149-91-7

1034-01-1

Gallic acid (0.3 mmol, 50 mg), octanol (0.9 mmol) and concentrated sulfuric acid (0.07 mL) were added to the microwave reaction flask. After sealing the reaction bottle, it was placed in a microwave reactor and the reaction was radiated at 100 °C for 50 min. After completion of the reaction, it was cooled to room temperature and the volatile components of the reaction mixture were evaporated to dryness. The residue was dissolved with ethyl acetate (30 mL) and washed sequentially with saturated sodium bicarbonate solution (3 x 20 mL) and sodium chloride solution (1 x 20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was purified by column chromatography with the eluent being a solvent mixture of hexane/ethyl acetate in the ratio of 3:7, v/v/v/v. The melting point and spectral data of the target compound octyl gallate were in agreement with those reported in literature [25d]. The isolated yield of octyl gallate was 70% under the present experimental conditions.