H-AVPIAQK-OH

Smac-N7 peptide, the seven N-terminal amino acid of the mitochondrial protein Smac (second mitochondria-derived activator of caspase), cannot pass through the cell membrane[1].

Cell permeable: no', 'Kd ~800 nM in binding to the BIR2 and BIR3 (baculovirus IAP repeat) domains of XIAP (X-linked inhibitor of apoptosis proteins)', 'Primary Target
Promotes the catalytic activity of caspase-9 in the presence of XIAP', 'Product does not compete with ATP.', 'Reversible: no

[1] S Heckl, et al. A novel polyarginine containing Smac peptide conjugate that mediates cell death in tumor and healthy cells. Med Chem. 2008 Jul;4(4):348-54. DOI:10.2174/157340608784872217