Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties[1][2].
in vivo
Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%[2].
Animal Model:
LPS-Induced Shock Mice[2]
Dosage:
50 mg/kg
Administration:
I.p.
Result:
Markedly decreased the mortality to 20%.
References
[1] Eisenkraft A. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016;173(11):1719-1727. DOI:10.1111/bph.13486 [2] Liu C, et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med. 2009;37(2):634-641. DOI:10.1097/CCM.0b013e31819598f5
