REVEROMYCIN D

Product NameREVEROMYCIN D
CAS144860-70-8
MFC37H54O11
MW674.82
EINECS
MOL File144860-70-8.mol

Chemical Properties

Boiling point	855.3±65.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	White to tan solid.
pka	4.36±0.17(Predicted)

Usage And Synthesis

Description

Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μg/ml at pH 3 and 7.4, respectively). Reveromycin D also inhibits proliferation of KB and K562 cells (IC₅₀s = 1.6 and 1.3 μg/ml, respectively).

Uses

Reveromycin D is a minor component of the reveromycin complex.

Uses

Reveromycin D is the isopentyl analogue and a minor component of the reveromycin complex, isolated from a Streptomyces sp.. Published information on reveromycin D suggests that it is more active than its straight chain analogue, reveromycin C.

References

[1] H TAKAHASHI. Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties.[J]. Journal of Antibiotics, 1992, 45 9: 1409-1413. DOI: 10.7164/antibiotics.45.1409
[2] H TAKAHASHI. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities.[J]. Journal of Antibiotics, 1992, 45 9: 1414-1419. DOI: 10.7164/antibiotics.45.1414