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S-Trityl-L-cysteine

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S-Trityl-L-cysteine Basic information
S-Trityl-L-cysteine Chemical Properties
  • Melting point:182-183 °C (dec.)(lit.)
  • Boiling point:524.7±50.0 °C(Predicted)
  • Density 1.1342 (rough estimate)
  • refractive index 111 ° (C=0.8, 0.04mol Ethanolic HCl)
  • storage temp. Sealed in dry,Room Temperature
  • pka2.22±0.10(Predicted)
  • form White to off-white solid.
  • optical activity[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl
  • BRN 2339626
  • CAS DataBase Reference2799-07-7(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22
  • Safety Statements 22-24/25
  • WGK Germany 3
  • RTECS AY7710000
  • HS Code 29309090
MSDS
S-Trityl-L-cysteine Usage And Synthesis
  • Chemical Propertiesalmost white to light yellow granular powder
  • UsesA protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.
  • Biological ActivityPotent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity.
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