Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation[1].
Definition
ChEBI: A tricyclic diterpenoid with formula C20H24O4, originally isolated from Tripterygium wilfordii.
References
[1] Moritoki H, et al. Inhibition by triptoquinone-A of LPS- and IL-1 beta-primed induction of NO synthase in rat thoracic aorta. Life Sci. 1996;59(3):PL49-54. DOI:10.1016/0024-3205(96)00283-4
