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Pantoprazole

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Pantoprazole Basic information
Pantoprazole Chemical Properties
  • Melting point:139-140° (dec)
  • Boiling point:586.9±60.0 °C(Predicted)
  • Density 1.51±0.1 g/cm3(Predicted)
  • pkapKa1 3.92; pKa2 8.19(at 25℃)
  • CAS DataBase Reference102625-70-7(CAS DataBase Reference)
Safety Information
Pantoprazole Usage And Synthesis
  • DescriptionPantoprazole, an irreversible proton pump inhibitor, reached its first market worldwide in Germany for acute treatment of gastric and duodenal ulcers and gastroesophageal reflux disease. Proton pump inhibitors are more effective than other strategies in inhibiting acid secretion since they function at the final step of acid production, therefore, provide superior symptom relief and healing in all acid related diseases. As the third substituted benzimidazole proton pump inhibitor marketed, pantoprazole not only has superior ulcer-preventing effect but also is more potent than omeprazole in healing acetic acid-induced gastric and duodenal ulcers with extremely low acute toxicity. The mechanism of action for this class of compounds has been suggested to be mediated via the protonated form of the molecule which selectively reacts with cysteines present on the extracytoplasmic face of the enzyme to form covalent disulfide bonds.
  • OriginatorByk Gulden (Germany)
  • Usesproton pump inhibitor, gastric acid release inhibitor, antiulcer
  • DefinitionChEBI: A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.
  • brand namePantozol; Rifun
  • Veterinary Drugs and TreatmentsPantoprazole may be useful in treating or preventing gastric acidrelated pathologies in dogs, cats, foals and camelids, particularly when the intravenous route is preferred. Pantoprazole is available in both intravenous and oral tablet (delayed-release) formulations. One study (Bersenas, Mathews et al. 2005) performed in dogs, comparing the gastric pH effects of intravenous pantoprazole with oral omeprazole, intravenous ranitidine, and intravenous famotidine, found at the dosages used, that pantoprazole was more effective than ranitidine, but similar to famotidine, and that oral omeprazole was more effective in maintaining intragastric pH >3 for a longer period than pantoprazole.
    Pantoprazole has been shown to directly reduce in vitro counts of H. pylori and is used in some H. pylori treatment protocols for humans.
Pantoprazole Preparation Products And Raw materials
Pantoprazole(102625-70-7)Related Product Information
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