Syntestan,Syntex,W. Germany,1980
A mixture of 5 g of the 21-acetate of 6α-chlorohydrocortisone, 7 g of chloranil
and 100 cc of n-amyl alcohol was refluxed for 16 hours, cooled and diluted
with ether. The solution was successively washed with water, 5% sodium
carbonate solution and water, dried over anhydrous sodium sulfate, filtered
and evaporated to dryness under reduced pressure. Chromatographic
purification of the residue yielded the 21-acetate of 6-chloro-δ1,4,6-
pregnatriene-11β,17α,21-triol-3,20-dione.
