QUAZINONE

Ro 13-6438 (70018-51-8) is a selective inhibitor of phosphodiesterase III (PDE III, IC50 = 0.6 μM).

Quazinone (Ro 13-6438) is a phosphodiesterase inhibitor and novel cardiotonic agent with vasodilating properties.

Cardiotonic.

[1] R EIGENMANN  M H  M Gerold. Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties.[J]. Journal of Cardiovascular Pharmacology, 1984, 6 3: 511-519. DOI:10.1097/00005344-198405000-00021
[2] M HOLCK. Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties.[J]. Journal of Cardiovascular Pharmacology, 1984, 6 3: 520-530. DOI:10.1097/00005344-198405000-00022