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ZAPRINAST

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ZAPRINAST Basic information
ZAPRINAST Chemical Properties
  • Melting point:237-238°C dec.
  • Density 1.48±0.1 g/cm3(Predicted)
  • RTECS XZ6157358
  • storage temp. Store at RT
  • solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL
  • form solid
  • pka6.92±0.20(Predicted)
  • color white
  • CAS DataBase Reference37762-06-4
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
MSDS
ZAPRINAST Usage And Synthesis
  • Chemical PropertiesZaprinast is Yellow-Orange Crystalline Powder
  • UsescGMP phosphodiesterase inhibitor
  • UsesZaprinast is  a  selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of at rial natriuretic factor (ANF) through the activation of PKG (cGMP dependent protein kinase), such inhibitors may display vasodilating, relaxant, and diuretic effects. These compounds may prove useful in treating hypertension and congestive heart failure.
  • Biological ActivityPhosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC 50 values are 0.15, 0.76, 12.0 and 29.0 μ M respectively).
ZAPRINAST(37762-06-4)Related Product Information
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