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ZAPRINAST

ZAPRINAST Structure
ZAPRINAST
  • CAS No.37762-06-4
  • Chemical Name:ZAPRINAST
  • CBNumber:CB3215496
  • Molecular Formula:C13H13N5O2
  • Formula Weight:271.27
  • MOL File:37762-06-4.mol
ZAPRINAST Property
  • Melting point: :237-238°C dec.
  • Density  :1.48±0.1 g/cm3(Predicted)
  • RTECS  :XZ6157358
  • storage temp.  :Store at RT
  • solubility  :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL
  • form  :solid
  • pka :6.92±0.20(Predicted)
  • color  :white
  • CAS DataBase Reference :37762-06-4
  • FDA UNII :GXT25D5DS0
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
ZAPRINAST Price More Price(36)
  • Brand: Sigma-Aldrich
  • Product number: 684500
  • Product name : Zaprinast
  • Purity: 
  • Packaging: 25mg
  • Price: $78.2
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: Z0878
  • Product name : Zaprinast
  • Purity: solid
  • Packaging: 25mg
  • Price: $81.2
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63326
  • Product name : Zaprinast, 98+%
  • Purity: 
  • Packaging: 50mg
  • Price: $269
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63326
  • Product name : Zaprinast, 98+%
  • Purity: 
  • Packaging: 10mg
  • Price: $62.3
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 10010421
  • Product name : Zaprinast
  • Purity: ≥98%
  • Packaging: 10mg
  • Price: $21
  • Updated: 2021/12/16
  • Buy: Buy

ZAPRINAST Chemical Properties,Usage,Production

  • Description The cyclic nucleotide second messenger guanosine 3’5’-cyclic monophosphate (cGMP) is an important mediator of signal transduction and hence a wide range of cellular processes. It can be generated by soluble guanylyl cyclase in response to binding of nitric oxide and degraded via members of the phosphodiesterase (PDE) protein family. Zaprinast, the compound from which sildenafil (Viagra?) was developed, is a cGMP-specific phosphodiesterase inhibitor. It moderately inhibits PDE5 and PDE6 with IC50 values of 0.5-0.76 and 0.15 μM, respectively, and weakly inhibits PDE9, PDE10, and PDE11 with IC50 values of 35, 22, and 11-33 μM, respectively. Zaprinast therefore enhances the vasodilatory effects of nitric oxide in a range of vascular tissues by prolonging the cGMP-mediated activation of cGMP-dependent protein kinase. Zaprinast also activates both the rat and human G protein-coupled receptor, GPR35 with EC50 values of 16 nM and 0.84 μM, respectively.
  • Chemical Properties Zaprinast is Yellow-Orange Crystalline Powder
  • Uses cGMP phosphodiesterase inhibitor
  • Uses Zaprinast is  a  selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of at rial natriuretic factor (ANF) through the activation of PKG (cGMP dependent protein kinase), such inhibitors may display vasodilating, relaxant, and diuretic effects. These compounds may prove useful in treating hypertension and congestive heart failure.
  • Uses
    Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.
  • Biological Activity Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC 50 values are 0.15, 0.76, 12.0 and 29.0 μ M respectively).
  • Biochem/physiol Actions Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.
ZAPRINAST Preparation Products And Raw materials
Raw materials
Preparation Products
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37762-06-4, ZAPRINASTRelated Search:
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  • ZAPRINAST
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  • M&B 22,948
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  • 2-(2-Propoxyphenyl)-8-azahypoxanthine
  • Phenylaza purinon
  • 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 3,6-dihydro-5-(2-propoxyphenyl)-
  • ZAPRINAST USP/EP/BP
  • 37762-06-4
  • C13H13N5O2
  • Phosphodiesterase Inhibitors
  • Cyclic Nucleotide Metabolism
  • G Proteins and Cyclic Nucleotides
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Cyclic Nucleotide related