DIPHTHERIA TOXIN

Diphtheria Toxin, CRM Mutant is an agent that does not have NAD:EF2 ADP-ribosyltransferase activity.

Diphtheria toxin may be used as a toxin element in the construction of immunotoxin for cell specific cytotoxicity. The translocation domain of bacterial toxins with natural endosome escape mechanism has been used in the development of efficient nonviral vectors for applications in gene therapy.

Inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II.

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[2] MURPHY J R. Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process.[J]. Toxins, 2011, 3 3: 294-308. DOI: 10.3390/toxins3030294
[3] MAREIKE BÜTEPAGE. Intracellular Mono-ADP-Ribosylation in Signaling and Disease.[J]. Cells, 2015, 4 4: 569-595. DOI: 10.3390/cells4040569