槐角苷 性质
| 熔点 | 298° |
|---|---|
| 比旋光度 | D20 -47° (pyridine); D20 -32° (10% aq pyridine) |
| 沸点 | 466.08°C (rough estimate) |
| 密度 | 1.3597 (rough estimate) |
| 折射率 | 1.5376 (estimate) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | 可溶于水基（轻微）、DMSO（轻微、加热）、吡啶（轻微、超声处理） |
| 酸度系数(pKa) | 6.45±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅棕色 |
| 最大波长(λmax) | 271nm(MeOH)(lit.) |
| 主要应用 | 代谢组学 维生素、营养保健品和天然产品 |
| InChIKey | ISQRJFLLIDGZEP-JNAFRSBINA-N |
| SMILES | C12C(O)=CC(O)=CC=1OC=C(C1C=CC(O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO)O3)O)=CC=1)C2=O |&1:16,17,19,20,22,r| |
| CAS 数据库 | 152-95-4(CAS DataBase Reference) |
槐角苷 用途与合成方法
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. The results show that Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner.
When the Sophoricoside is orally administered 1 h before compound 48/80 injections, the scratching behaviors is reduced. The inhibition rate of Sophoricoside (2 mg/kg) is approximately 41.21%. Orally administered Sophoricoside inhibits the scratching behaviors by 47.31%. When mice are treated for 2 weeks with Sophoricoside, the atopic dermatitis is recovered to a significant extent.
槐角苷 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-N0423R | 槐角苷 | 152-95-4 | 5 mg | 360 |
| 2026-09-15 | HY-N0423R | 槐角苷 | 152-95-4 | 10 mg | 540 |
