槐角苷

概述生物活性体外研究体内研究槐角苷试剂级价格

槐角苷

CAS号:152-95-4
英文名:Sophoricoside
中文名:槐角苷
CBNumber:CB7446261
分子式:C21H20O10
分子量:432.38
MOL File:152-95-4.mol

槐角苷化学性质

熔点 :298°
比旋光度 :D20 -47° (pyridine); D20 -32° (10% aq pyridine)
沸点 :466.08°C (rough estimate)
密度 :1.3597 (rough estimate)
折射率 :1.5376 (estimate)
储存条件 :under inert gas (nitrogen or Argon) at 2–8 °C
溶解度 :Aqueous Base (Slightly), DMSO (Slightly, Heated), Pyridine (Slightly, Sonicated)
酸度系数(pKa) :6.45±0.20(Predicted)
形态 :Solid
颜色 :White to Light Brown
最大波长(λmax) :271nm(MeOH)(lit.)
CAS 数据库 :152-95-4(CAS DataBase Reference)

安全信息

安全说明 :22-24/25
海关编码 :29329990

槐角苷性质、用途与生产工艺

概述现代药理研究表明，槐角苷对慢性肝炎病人的降谷丙转氨酶效果良好，还能同时抑制由巴豆油诱导的耳水肿和角叉菜胶引起的爪水肿。临床研究也证实，槐角苷可用于防治妇女绝经后骨质疏松的症状。
生物活性 Sophoricoside 是一种从槐花中分离得到的异黄酮糖苷，具有抗炎，抗癌和免疫抑制作用。
体外研究

Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. The results show that Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner.
体内研究

When the Sophoricoside is orally administered 1 h before compound 48/80 injections, the scratching behaviors is reduced. The inhibition rate of Sophoricoside (2 mg/kg) is approximately 41.21%. Orally administered Sophoricoside inhibits the scratching behaviors by 47.31%. When mice are treated for 2 weeks with Sophoricoside, the atopic dermatitis is recovered to a significant extent.
化学性质白色结晶粉末，溶于甲醇，来源于槐角。
用途升血糖作用；槐角浸羔注射于家兔，能使血糖一时性增高。据南京药物研究所报道，从槐角中提出的染料木素和山柰酚，具有干扰孕卵运输、终止孕卵着床和抗早期妊娠等作用，可能与其雌性激素活性有关；小量长期服用染料木素和槐角甙，对雌性小鼠在不影响交配率和生长的情况下，有显著的抗生育作用。毒性作用，槐角浸羔能使家兔及豚鼠的红细胞减少，尤以荚果作用为大。槐树种子提取液能使兔、猪、人的红细胞凝集，种子、荚、果肉均含有抗A、抗B、抗H凝集素；中国槐为含有植物血凝素类药物，并具有促进淋巴细胞的转化作用