3,5-Di-O-(tert-butyldimethylsilyl)-2-deoxy-D-ribonolactone

(4S,5R)-4-(tert-Butyldimethylsilyloxy)-5-((tert-butyldimethylsilyloxy)methyl)dihydrofuran-2(3H)-one is used as a reactant in the synthesis of 6-substituted pyridin-3-yl C-nucleosides using Heck arylation, palladium-catalyzed cross-coupling, amination, and alkoxylation reactions.