ChemicalBook Product Catalog Biochemical Engineering Natural Products Icariin

Icariin

Product NameIcariin

CAS489-32-7

MFC33H40O15

MW676.66

EINECS610-440-0

Chemical Properties

Melting point	223-225 ºC
alpha	D15 -87.09° (in pyridine)
Boiling point	948.5±65.0 °C(Predicted)
Density	1.55
RTECS	DJ2980500
storage temp.	2-8°C
solubility	DMSO: soluble50mg/mL, clear, colorless to dark yellow
form	Powder
pka	5.90±0.40(Predicted)
color	light yellow to yellow
λmax	350nm(MeOH)(lit.)
Merck	14,3617
InChIKey	TZJALUIVHRYQQB-XLRXWWTNSA-N

Safety Information

Safety Statements	24/25
WGK Germany	3
HS Code	29389090

Usage And Synthesis

Applications

Icariin inhibits the ROS-dependent JNK and p38 pathways.
Description

Icariin is one of the major flavonoids of the herb Epimedium, which has long been used in Tranditional Chinese Medicine to treat bone fracture and prevent osteoporosis. Research has shown that icariin should be an effective component for the bone-strengthening activity of the herb Epimedium, and one of the possible mechanisms for this activity is to stimulate the proliferation and enhance the osteogenic differentiation of marrow stromal cells. Icariin is reported to prevent and treat sexual dysfunction related diseases and improve the use of vasoconstriction. Icariin is used to prepare angiotensin converting enzyme inhibitor medicines, which can be used to treat hypertension-complicated coronary diseases.
References

[1] K. M. Chen, B. F. Ge, H. P. Ma, X. Y. Liu, M. H. Bai, Y, Wang (2005) Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells, 60, 939-942
[2] Patent CN 1199647C “Application of icariin in preparation of medicine for preventing and treating sexual dysfunction”
[3] Patent CN 104739851 A “New application of icariin, or icariin derivatives or icariin salt”
Chemical Properties

Light yellow to yellow solid
Uses
Icariin has been used:
- in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats
- to test its analgesic effects on lower back pain (LBP) in rats
- as a potential treatment in osteoporosis condition in rats
- to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes
- as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells
Uses

hepatoprotective
Uses

Icariin has been used as a test material to investigate its, in vitro effect in promoting mouse hair follicle growth, which is assessed by vibrissae hair follicle (VHF) organ-culture model.
General Description

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.
Biochem/physiol Actions

Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.

Icariin Supplier

Icariin manufacturers

Related Product Information

Send Inquriy

Icariin

Usage And Synthesis

Icariin Supplier

Icariin manufacturers

Related articles

Related Product Information