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Quinolinic acid

Product NameQuinolinic acid





MOL File89-00-9.mol

Chemical Properties

Melting point 188-190 °C (dec.) (lit.)
Boiling point 295.67°C (rough estimate)
Density  1.5216 (rough estimate)
refractive index  1.6280 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  10g/l
form  Crystalline Powder
pka 2.43(at 25℃)
color  White to light yellow-beige
Water Solubility  0.55 g/100 mL
Merck  14,8073
BRN  137110
CAS DataBase Reference 89-00-9(CAS DataBase Reference)
EPA Substance Registry System 2,3-Pyridinedicarboxylic acid (89-00-9)

Safety Information

Hazard Codes  Xi
Risk Statements  36/37/38-33
Safety Statements  26-36/37-24/25-37
WGK Germany  3
RTECS  US7967250
HazardClass  IRRITANT
HS Code  29333999
Hazardous Substances Data 89-00-9(Hazardous Substances Data)
Toxicity Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur.


Usage And Synthesis

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