8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea[1].
References
[1] Youn UJ, et al. Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62. DOI:10.1016/j.bmcl.2012.07.010
