It is a white crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from Astragalus membranaceus (Fisch.) Bunge.
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].
ChEBI: Astrapterocarpan is a member of pterocarpans.
PDGFR: 10 μM (IC50); ERK1; ERK2
[1] Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005 Nov 21;525(1-3):41-7. DOI:
10.1016/j.ejphar.2005.08.063
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