White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Astragalus and Licorice.
Ononin is an isoflavone compound from Glycyrrhiza uralensis is the 7-O-glucoside of Formononetin (F693200), an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen.
ChEBI: A methoxyisoflavone that is formononetin attached to a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
A isoflavone glucoside found in soybean, kudzu, and the Chinese medicinal herb, Radix astragali (RA). RA is a supplement taken to improve "energy." It may act by inducing erythropoietin expression.
Ononin (30 mg/kg, p.o., 12 days) shows neuroprotective effects against aluminium chloride-induced Alzheimer’s disease in rats[4].
Ononin (10-50 mg/kg, p.o., once a day for 60days) mitigates Streptozotocin (HY-13753)-induced diabetic nephropathy in rats via alleviating oxidative stress and inflammatory markers[5].
Ononin (30-60 mg/kg/day, gavage, 8 weeks) alleviates endoplasmic reticulum stress in Doxorubicin (HY-15142A)-induced cardiotoxicity in rats by activating SIRT3[6].
