Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Astragalus and Licorice.
Uses
Ononin is an isoflavone compound from Glycyrrhiza uralensis is the 7-O-glucoside of Formononetin (F693200), an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen.
Definition
ChEBI: A methoxyisoflavone that is formononetin attached to a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Biological Activity
A isoflavone glucoside found in soybean, kudzu, and the Chinese medicinal herb, Radix astragali (RA). RA is a supplement taken to improve "energy." It may act by inducing erythropoietin expression.
in vivo
Ononin (30 mg/kg, p.o., 12 days) shows neuroprotective effects against aluminium chloride-induced Alzheimer’s disease in rats[4].
Ononin (10-50 mg/kg, p.o., once a day for 60days) mitigates Streptozotocin (HY-13753)-induced diabetic nephropathy in rats via alleviating oxidative stress and inflammatory markers[5].
Ononin (30-60 mg/kg/day, gavage, 8 weeks) alleviates endoplasmic reticulum stress in Doxorubicin (HY-15142A)-induced cardiotoxicity in rats by activating SIRT3[6].
