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Cyclobutanone

Cyclobutanone is an organic compound with a four-membered cyclic ketone. It is used in preparation of cyclobutane derivatives, as a starting material for aminocyclobutanecarboxylic acid through sulfonyloxiranes, to prepare dihydro-furan-2-one in presence of polystyrene-bound phenylselenic acid as catalyst. It is also involved in the photochemical synthesis of nucleoside analogues such as bicyclic nucleosides and isonucleosides.

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Cyclobutanone Basic information
Cyclobutanone Chemical Properties
  • Melting point:-50.9 °C
  • Boiling point:99 °C (lit.)
  • Density 0.938 g/mL at 25 °C (lit.)
  • refractive index n20/D 1.421(lit.)
  • Flash point:50 °F
  • storage temp. 2-8°C
  • form Liquid
  • Specific Gravity0.938
  • color Clear colorless to slightly yellow
  • Water Solubility INSOLUBLE
  • BRN 1560289
  • InChIKeySHQSVMDWKBRBGB-UHFFFAOYSA-N
  • CAS DataBase Reference1191-95-3(CAS DataBase Reference)
  • EPA Substance Registry SystemCyclobutanone (1191-95-3)
Safety Information
  • Hazard Codes F,F+
  • Risk Statements 10-11
  • Safety Statements 23-24/25-9-33-29-16-7/9
  • RIDADR UN 1224 3/PG 3
  • WGK Germany 3
  • TSCA Yes
  • HazardClass 3
  • PackingGroup II
  • HS Code 29142900
MSDS
Cyclobutanone Usage And Synthesis
  • DescriptionCyclobutanone is an organic compound with a four-membered cyclic ketone. It is used in preparation of cyclobutane derivatives, as a starting material for aminocyclobutanecarboxylic acid through sulfonyloxiranes, to prepare dihydro-furan-2-one in presence of polystyrene-bound phenylselenic acid as catalyst. It is also involved in the photochemical synthesis of nucleoside analogues such as bicyclic nucleosides and isonucleosides. Furthermore, it is used to synthesis fatty acid, 2-oxo-cyclobutane undecanoic acid, which is used in the development of an enzyme-linked immunosorbent assy for the detection of irradiated foods.
  • References[1] https://en.wikipedia.org/wiki/Cyclobutanone
    [2] https://www.alfa.com/de/catalog/A13068/
    [3] https://www.scbt.com/scbt/de/product/2-oxo-cyclobutane-undecanoic-acid-169263-77-8/;jsessionid=Ay2KMCxORq9y-EC6YoYnGGtCnymUGxQi5Lpd-YuCZoW22Re8Xf4w!-2072765631
  • Chemical PropertiesClear colourless to slightly yellow liquid
  • UsesCyclobutanone is used in preparation of cyclobutane derivatives. It is used as a starting material for aminocyclobutanecarboxylic acid through sulfonyloxiranes. It is also used to prepare dihydro-furan-2-one in presence of polystyrene-bound phenylselenic acid as catalyst. Further, it is involved in the photochemical synthesis of nucleoside analogues such as bicyclic nucleosides and isonucleosides.
  • Purification MethodsTreat cyclobutanone with dilute aqueous KMnO4, dry it with molecular sieves and fractionally distil it. Purify it via the semicarbazone, then regenerate the ketone, dry it (CaSO4), and distil it in a stainless steel spinning-band (or Vigreux, p 11) column. Alternatively, purify it by preparative gas chromatography using a Carbowax 20-M column at 80o. (This treatment also removes acetone). The oxime has m 84-85o (from pet ether) and the semicarbazone has m 212-212-5o (220-221o from MeOH or H2O, Buchanan et al. J Am Chem Soc 64 2701 1942). [Salaun Org Synth 57 36 1977, Fitzer & Quabeck Synthesis 299 1987, Beilstein 7 IV 3.]
Cyclobutanone Preparation Products And Raw materials
Cyclobutanone(1191-95-3)Related Product Information
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    Purity:95+% Package:1g;5g;10g
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