White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Ilex pubescens.
Rotundic acid, a triterpenoid obtained from Ilex rotunda Thunb., induces DNA damage and cell apoptosis in hepatocellular carcinoma through AKT/mTOR and MAPK Pathways. Rotundic acid possesses anti-inflammatory and cardio-protective abilities[1].
ChEBI: A natural product found in Euscaphis japonica.
[1] Roy G, et al. Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways. Front Oncol. 2019 Jun 26;9:545. DOI:
10.3389/fonc.2019.00545
