trans-1,3-dichloropropene, catalyst, and organic amine are added to the solvent tetrahydrofuran. Under stirring, tert-butylacetylene is added dropwise at 40°C. After the addition is complete, the reaction continues for 10-50 hours, preferably 30 hours. After the reaction is complete, tetrahydrofuran is removed by vacuum distillation. The product is dissolved in petroleum ether, washed three times with dilute ammonia solution with a weight percentage of 8-12%, dried, filtered, and then the petroleum ether is removed by vacuum distillation to obtain a crude product. The crude product is then subjected to vacuum distillation, and the fraction collected at 70-80°C (15 mmHg) is used to obtain a colorless to pale yellow product, 1-Chloro-6,6-dimethyl-2-heptene-4-yne.
1-Chloro-6,6-dimethyl-2-heptene-4-yne is an intermediate in the synthesis of terbinafine, an orally administered antifungal drug. It can be used to treat fungal infections of the scalp, body, groin (ringworm), feet (tinea pedis), fingernails and toenails.
1-Chloro-6,6-dimethyl-2-heptene-4-yne is an intermediate in the synthesis of Terbinafine (T107500).
1-Chloro-6,6-dimethyl-2-heptene-4-yne causes skin irritation and serious eye irritation, it may cause respiratory irritation.
1-Chloro-6,6-dimethyl-2-heptene-4-yne is stable under normal conditions, it reacts with strong oxidizing agents.
