1-(4-Chlorophenyl)-1-cyclopropanecarboxylic acid

64399-27-5

72934-37-3

The general procedure for the synthesis of 1-(4-chlorophenyl)-1-cyclopropanecarboxylic acid from 1-(4-chlorophenyl)-1-cyclopropanecarbonitrile is as follows: 1-(4-chlorophenyl)-1-cyclopropanecarbonitrile (18 g) obtained in Example 1 was added to 20% sulfuric acid solution (184 mL). The temperature was slowly raised to reflux and the reaction was maintained for 10-12 hours. Upon completion of the reaction, the reaction mixture was extracted using ethyl acetate. Subsequently, the carboxylic acid product in the organic layer was transferred to 20% sodium hydroxide solution for extraction. The aqueous phase was acidified to pH 2-4 with concentrated hydrochloric acid and a white solid product was precipitated. The solid was collected by filtration and washed with distilled water. After drying, 1-(4-chlorophenyl)-1-cyclopropanecarboxylic acid was obtained in 90-95% yield, 99.4% purity by HPLC and 152-155°C melting point.