龙胆苦苷
龙胆苦苷 性质
| 熔点 | 191°C |
|---|---|
| 比旋光度 | -200 º (c=2, H2O) |
| 沸点 | 667.8±55.0 °C(Predicted) |
| 密度 | 1.52±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 可溶于DMSO（轻微）、乙醇（轻微、超声处理） |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.79±0.70(Predicted) |
| 颜色 | 浅米色 |
| 生物来源 | plant (Gentiana macrophylla Pall) |
| 旋光度 (Optical Rotation) | [α]/D -185 to -205°, c =1 in H2O |
| 水溶解性 | H2O: 20mg/mL, clear |
| 稳定性 | 吸湿性 |
| 主要应用 | metabolomics vitamins, nutraceuticals, and natural products |
| InChI | 1S/C16H20O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2-3,6-7,10-13,15-20H,1,4-5H2/t7-,10-,11-,12+,13-,15+,16+/m1/s1 |
| InChIKey | DUAGQYUORDTXOR-GPQRQXLASA-N |
| SMILES | C=C[C@H]1[C@H](O[C@]2([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C3C(OCC=C31)=O |
| LogP | -3.170 (est) |
| CAS 数据库 | 20831-76-9(CAS DataBase Reference) |
龙胆苦苷 用途与合成方法
龙胆苦苷（Gentiopicroside, GPS）是龙胆科植物（如秦艽、龙胆草）中的主要活性成分，为环烯醚萜苷类，分子式为C16H20O9，具有保护肝脏、抗氧化、抗炎、镇痛、改善糖尿病并发症以及调节糖代谢等作用。GPS被中华人民共和国药典收录作为龙胆药材的活性物质测试指标。
龙胆苦苷是一种天然的环烯醚萜苷，能够抑制 P450 的活性，对 CYP2A6 的 IC50 和 Ki 值分别为 61 µM 和 22.8 µM；Gentiopicroside 具有抗炎和抗氧化活性。
| Target | Value |
|
CYP2A6
(in human liver microsomes) | |
|
CYP2E1
(in human liver microsomes) |
Gentiopicroside inhibits P450 activity, with an IC 50 and a K i of 61 µM and 8.12 µM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC 50 of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50 μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50 μM) also inhibits RANKL-induced bone resorption.
Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice.
药理药效:具有利胆、抗炎、健胃、降压等作用。
龙胆苦苷 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-03-03 | 46683 | 龙胆苦苷 | 20831-76-9 | 250mg | 2539 |
| 2026-03-03 | S3777 | 龙胆苦苷 | 20831-76-9 | 10mg | 795.05 |
