龙胆苦苷

生物活性靶点体外研究体内研究龙胆苦苷试剂级价格

龙胆苦苷

CAS号:20831-76-9
英文名:Gentiopicroside
中文名:龙胆苦苷
CBNumber:CB7110834
分子式:C16H20O9
分子量:356.33
MOL File:20831-76-9.mol

龙胆苦苷化学性质

熔点 :191°C
比旋光度 :-200 º (c=2, H2O)
沸点 :667.8±55.0 °C(Predicted)
密度 :1.52±0.1 g/cm3(Predicted)
储存条件 :2-8°C(protect from light)
溶解度 :DMSO (Slightly), Ethanol (Slightly, Sonicated)
形态 :Solid
酸度系数(pKa) :12.79±0.70(Predicted)
颜色 :Pale Beige
稳定性 :Hygroscopic
LogP :-3.170 (est)
CAS 数据库 :20831-76-9(CAS DataBase Reference)

安全信息

海关编码 :29389090

龙胆苦苷 MSDS

Gentiopicrin

龙胆苦苷性质、用途与生产工艺

生物活性
龙胆苦苷是一种天然的环烯醚萜苷，能够抑制 P450 的活性，对 CYP2A6 的 IC50 和 Ki 值分别为 61 µM 和 22.8 µM；Gentiopicroside 具有抗炎和抗氧化活性。
靶点
Target Value
CYP2A6
(in human liver microsomes)
CYP2E1
(in human liver microsomes)
体外研究

Gentiopicroside inhibits P450 activity, with an IC ₅₀ and a K _i of 61 µM and 8.12 µM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC ₅₀ of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50 μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50 μM) also inhibits RANKL-induced bone resorption.
体内研究

Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice.
化学性质类白色结晶粉末，易溶于甲醇，几乎不溶于乙醚，来源于长梗秦艽（西藏，甘肃）秦艽根茎龙胆，苦胆草。
用途龙胆苦苷具有利胆、抗炎、健胃、降压的作用。
用途用于含量测定/鉴定/药理实验等。
药理药效:具有利胆、抗炎、健胃、降压等作用。