ARPHAMENINE B

Arphamenine B is a Zn2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B enhances the immune response and is used to characterize novel proteases[1][2][3].

[1] Foulon T, et al. Aminopeptidase B (EC 3.4.11.6). Int J Biochem Cell Biol. 1999 Jul;31(7):747-50. DOI:10.1016/s1357-2725(99)00021-7
[2] Umezawa H, et al. Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria. J Antibiot (Tokyo). 1983 Nov;36(11):1572-5. DOI:10.7164/antibiotics.36.1572
[3] Kubo H, et al. Involvement of sperm proteases in the binding of sperm to the vitelline envelope in Xenopus laevis. Zoolog Sci. 2008 Jan;25(1):80-7. DOI:10.2108/zsj.25.80