Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria . It is used to study organism-directed delivery of antibiotics as well as drug resistance .
Chemical structure: aminoglycoside
Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading.
Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3].
| Animal Model: | Male Fischer 344 rats (40-50-day-old)[3] |
| Dosage: | 320mg/kg |
| Administration: | Subcutaneous injection; daily; for 10 days |
| Result: | Induced hearing loss in rats.
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