2-(3-Chloropropyl)-1,3-dioxolane

Colorless liquid

2-(3-Chloropropyl)-1,3-dioxolane (2-(3′-chloropropyl)-1,3-dioxolane) is a masked γ-chlorobutyraldehyde and was used for the introduction of 3-(1,3-dioxolan-2-yl)propyl moiety. It was also used in the synthesis of:

• (±)-histrionicotoxin and (±)-histrionicotoxin 235A using a two-directional strategy
• 4-iodobutyraldehyde, 5-iodovaleraldehyde and 5-iodo-2-petanone
• corresponding phosphonate