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L-Citrulline

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L-Citrulline Basic information
L-Citrulline Chemical Properties
  • Melting point:214 °C
  • alpha 25.5 º (c=8, 6N HCl)
  • Boiling point:306.48°C (rough estimate)
  • Density 1.2919 (rough estimate)
  • refractive index 26 ° (C=8, 6mol/L HCl)
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • form Crystals or Crystalline Powder
  • pka2.43(at 25℃)
  • color White
  • OdorOdorless
  • Water Solubility 200 g/L (20 ºC)
  • Merck 14,2331
  • BRN 6055157
  • InChIKeyRHGKLRLOHDJJDR-BYPYZUCNSA-N
  • CAS DataBase Reference372-75-8(CAS DataBase Reference)
  • EPA Substance Registry SystemL-Ornithine, N5-(aminocarbonyl)- (372-75-8)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 24/25-36-26
  • WGK Germany 3
  • TSCA Yes
  • HS Code 29241900
MSDS
L-Citrulline Usage And Synthesis
  • Chemical PropertiesWhite powder
  • OriginatorStaminO2,ErgoPharm
  • UsesL-Citrulline, is used as an essential intermediate in the biosynthesis of nitric oxide from L-arginine . It is also used as a nutritional drink and biochemical reagent.
  • UsesAn amino acid, L-Citrulline can be used in the treatment of asthenia and as an essential intermediate in the biosynthesis of nitric oxide.
  • UsesAn essential intermediate in the biosynthesis of nitric oxide.
  • Manufacturing ProcessCitrulline is obtained as a result of a reaction of L-arginine hydrochloride with sodium hydroxide, copper oxide and hydrogen sulfide.
    In practice it is usually used as malate salt
  • Therapeutic FunctionStimulant, Detoxicant
  • Biochem/physiol ActionsL-Citrulline, when orally administered is found to ameliorate the condition of sickle cell disease in humans. L-citrulline can be a replacement for L-arginine administration in case of defective NO synthetase. L-Citrulline supplementation is found to fulfill the purpose of NO-dependent signaling.
  • Purification MethodsLikely impurities are arginine and ornithine. Crystallise S-citrulline from water by adding 5 volumes of EtOH. Also crystallise it from water by addition of MeOH. [Ellenbogen J Am Chem Soc 74 5198 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2491-2494 1961, Beilstein 4 IV 2647.]
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