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Acetohydroxamic acid

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Acetohydroxamic acid Basic information
Acetohydroxamic acid Chemical Properties
  • Melting point:88-90 °C(lit.)
  • Boiling point:133.7°C (rough estimate)
  • Density 1.2269 (rough estimate)
  • refractive index 1.4264 (estimate)
  • storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
  • pka8.70(at 25℃)
  • form Crystalline Solid
  • color White to pale yellow
  • Water Solubility Soluble in water.
  • Sensitive Hygroscopic
  • Merck 14,63
  • BRN 1739019
  • Stability:Moisture and Temperature Sensitive
  • InChIKeyRRUDCFGSUDOHDG-UHFFFAOYSA-N
  • CAS DataBase Reference546-88-3(CAS DataBase Reference)
  • NIST Chemistry ReferenceAcetamide,N-hydroxy(546-88-3)
  • EPA Substance Registry SystemAcetohydroxamic acid (546-88-3)
Safety Information
MSDS
Acetohydroxamic acid Usage And Synthesis
  • DescriptionAcetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.
  • Chemical PropertiesWhite Crystalline Solid
  • OriginatorResearch Organics; Baylor Unk. (USA)
  • Usesurease inhibitor, antiurolithic, antbacterial
  • UsesA urease inhibitor. Used in the synthesis
  • brand nameLithostat (Mission).
  • Safety ProfileModerately toxic by intraperitonealroute. An experimental teratogen. Other experimentalreproductive effects. Mutation data reported. When heatedto decomposition it emits toxic fumes of NOx.
  • Veterinary Drugs and TreatmentsAcetohydroxamic acid can be used in dogs as adjunctive therapy in some cases of recurrent urolithiasis or in the treatment of persistent urinary tract infections caused by the following bacteria: E. coli, Klebsiella, Morganella morganii, Staphylococci spp., and Pseudomonas aeruginosa. Adverse effects limit its usefulness.
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