2-Amino-4-bromopyridine

207799-10-8

84249-14-9

General procedure for the synthesis of 2-amino-4-bromopyridine from 2-Boc amine-4-bromopyridine: 2-Boc amine-4-bromopyridine (200 mg, 0.73 mmol) was suspended in water (1 mL) and hydrobromic acid (1 mL, 48 wt% aqueous solution) was added. The reaction mixture was stirred at room temperature for 16 h before being poured into aqueous sodium bicarbonate (25 mL) and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (pure ethyl acetate as eluent) to give 2-amino-4-bromopyridine. Yield: 73 mg (58%). LC/MS retention time: 0.69 min. m/z by mass spectrometry (electrospray positive ion mode): 175, 173 [M+H]+.