o-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A
o-Toluidine and o-toluidine hydrochloride are used primarily as intermediates in the manufacture of more than 90 dyes and pigments (NCI 1979, IARC 1982, 2000). They are used in acid-fast dyestuffs, azo pigments and dyes, triarylmethane dyes, sulfur dyes, and indigo compounds and as a photographic dye. o-Toluidine is also used as an intermediate for synthetic rubber and rubber vulcanizing chemicals, pharmaceuticals, and pesticides and as a curing agent in epoxy resin systems. Other minor uses of o-toluidine and its hydrochloride salt are as an intermediate in organic synthesis and as an ingredient in a clinical laboratory reagent for glucose and hemoglobin analyses.
Green crystals or white crystalline solid. Melting point 215-217°F. Highly toxic.
O-TOLUIDINE HYDROCHLORIDE acts as a weak acid. Incompatible with oxidizing agents and with alkalis .
Flash point data for O-TOLUIDINE HYDROCHLORIDE are not available; however, O-TOLUIDINE HYDROCHLORIDE is probably combustible.
Confirmed carcinogen
with experimental carcinogenic data. Poison
by intraperitoneal route. Moderately toxic by
ingestion. Mutation data reported. When
heated to decomposition it emits very toxic
fumes of HCl and NOx. See also o-
TOLUIDINE.
o-Toluidine and o-toluidine hydrochloride are reasonably anticipatedto be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.
