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2'-Hydroxy-5'-methoxyacetophenone

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2'-Hydroxy-5'-methoxyacetophenone Basic information
2'-Hydroxy-5'-methoxyacetophenone Chemical Properties
  • Melting point:52 °C(lit.)
  • Boiling point:254.38°C (rough estimate)
  • Density 1.1708 (rough estimate)
  • refractive index 1.5500 (estimate)
  • Flash point:>230 °F
  • storage temp. Inert atmosphere,Room Temperature
  • form Crystalline Powder
  • pka10.65±0.18(Predicted)
  • color Yellow
  • BRN 1239364
  • InChIKeyMLIBGOFSXXWRIY-UHFFFAOYSA-N
  • CAS DataBase Reference705-15-7(CAS DataBase Reference)
  • NIST Chemistry ReferenceEthanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7)
Safety Information
MSDS
2'-Hydroxy-5'-methoxyacetophenone Usage And Synthesis
  • Chemical Propertiesyellow crystalline powder
  • Uses2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.
  • Preparationreparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, ? with potassium carbonate in acetone at r.t. (74%) ; ? with aqueous sodium hydroxide solution at reflux (35%).
  • Synthesis Reference(s)Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380
  • General Description
    2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.
2'-Hydroxy-5'-methoxyacetophenone(705-15-7)Related Product Information
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