ChemicalBook Product Catalog Catalyst and Auxiliary Polyethylene glycol derivatives Poly(ethylene glycol) diacrylate

Poly(ethylene glycol) diacrylate

Product NamePoly(ethylene glycol) diacrylate
CAS26570-48-9
MFC5H10O4
MW134.1305
EINECS251-228-4
MOL File26570-48-9.mol

Chemical Properties

Melting point	12-17 °C
Density	1.12 g/mL at 25 °C
refractive index	n20/D 1.47
Flash point	347 °F
storage temp.	-20°C
solubility	H₂O: soluble
form	Granular Solid
color	White to off-white
Water Solubility	Soluble in water.
Sensitive	Light Sensitive
α-end	acrylate
Ω-end	acrylate
InChI	InChI=1S/C3H4O2.C2H6O2/c1-2-3(4)5;3-1-2-4/h2H,1H2,(H,4,5);3-4H,1-2H2
InChIKey	FCDZZFLRLVQGEH-UHFFFAOYSA-N
SMILES	O([H])C([H])([H])C([H])([H])O[H].O([H])C(C([H])=C([H])[H])=O
EPA Substance Registry System	Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxo-2-propenyl)-.omega.-[(1-oxo-2-propenyl)oxy]- (26570-48-9)

Safety Information

Hazard Codes	Xi
Risk Statements	41-43-38
Safety Statements	26-36/37/39
WGK Germany	1
TSCA	TSCA listed
HS Code	2916.12.5050
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Description

Poly(ethylene glycol) diacrylate (PEGDA) is a blank slate hydrogel that gels rapidly at room temperature in the presence of a photoinitiator and light. PEGDA hydrogels are potent tools for uncovering basic cellular biology because they are considered biologically inert (“blank slate”), and their mechanical properties can be varied over an extensive range of moduli.PEGDA is an emerging scaffold for tissue engineering and regenerative medicine since polymerization can occur rapidly at room temperature, requires low energy input, has high water content, is elastic, and can be customized to include a variety of biological molecules.

Uses

PEGDA is used in dental compounds, offset inks, varnishes and flexible coatings.

Definition

ChEBI: Poly(ethylene glycol diacrylate) is a poly(ethylene glycol) compound terminated with acrylate groups.

General Description

Poly(ethylene glycol) diacrylate (PEGDA) is a polyethylene glycol (PEG) based material that is used as a prepolymer solution that can be used in the formation of a cross-linked polymeric system.

reaction suitability

reagent type: cross-linking reagent
reaction type: Polymerization Reactions

Synthesis

S1, polyethylene glycol (PEG) was dried in vacuum at 50C overnight, and K2CO3 was ground and dried in vacuum at 100C overnight, and cooled in vacuum;

S2, 50g of PEG was dissolved in 100mL of anhydrous dichloromethane in a three-necked flask of 500mL, and K2CO3 was added in accordance with the amount of additions shown in Table 2, and stirred well to disperse;

S3, according to the addition amount shown in Table 2, acryloyl chloride was dissolved in anhydrous dichloromethane (1:10v/v), and slowly added drop by drop to the three-necked flask, and the reaction was carried out for 24h at room temperature under the protection of nitrogen;

S4, the mixture was filtered to remove the solids, and the supernatant was rotary evaporated at 37 to remove most of the solvent and then fully precipitated with ether and washed by ether for 3-5 times, and finally the product was completely dried in a vacuum. The product, polyethylene glycol diacrylate (PEGDA), was completely dried in vacuum.