咖啡豆醇 性质
| 熔点 | 88-90℃ |
|---|---|
| 沸点 | 476.6±45.0 °C(Predicted) |
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | DMF:5.0(最大浓度 mg/mL);0.64(最大浓度 mM) DMSO:18.17(最大浓度 mg/mL);57.77(最大浓度 mM) 乙醇:5.0(最大浓度 mg/mL);0.64(最大浓度 mM) 乙醇:PBS (pH 7.2) (1:5):0.02(最大浓度 mg/mL);0.06(最大浓度 mM) |
| 酸度系数(pKa) | 14.43±0.40(Predicted) |
| 形态 | 白色至类白色固体。 |
| 颜色 | 米白色至浅黄色 |
| 主要应用 | 食品和饮料 |
| InChI | 1S/C20H26O3/c1-18-7-5-16-14(6-9-23-16)15(18)4-8-19-10-13(2-3-17(18)19)20(22,11-19)12-21/h5-7,9,13,15,17,21-22H,2-4,8,10-12H2,1H3/t13-,15-,17+,18-,19+,20+/m1/s1 |
| InChIKey | JEKMKNDURXDJAD-HWUKTEKMSA-N |
| SMILES | CC12C=Cc3occc3C1CCC45CC(CCC24)C(O)(CO)C5 |
| LogP | 3.380 (est) |
咖啡豆醇 用途与合成方法
AMPK; adipogenesis; apoptosis
Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells. Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells. Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only. kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells. kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism.
Western Blot Analysis
| Cell Line: | 3T3-L1 cells |
| Concentration: | 0, 5, 10, 25 μg/ml |
| Incubation Time: | |
| Result: | Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner. |
咖啡豆醇 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-N6258 | 咖啡豆醇 | 6894-43-5 | 1 mg | 790 |
| 2026-09-15 | HY-N6258 | 咖啡豆醇 | 6894-43-5 | 5mg | 1976 |
