Apramycin sulfate

Product NameApramycin sulfate
CAS41194-16-5
MFC21H43N5O15S
MW637.66
EINECS687-974-6
MOL File41194-16-5.mol

Chemical Properties

InChIKey	WGLYHYWDYPSNPF-XWJANVBINA-N
EPA Substance Registry System	D-Streptamine, O-4-amino-4-deoxy-.alpha.- D-glucopyranosyl-(1.fwdarw. 8)-O-(8R)-2-amino-2,3,7-trideoxy- 7-(methylamino)-D-glycero-. alpha.-D-allo-octodialdo- 1,5:8,4-dipyranosyl-(1.fwdarw. 4)-2-deoxy-(41194-16-5)

Usage And Synthesis

Description

Apramycin was found in the culture broth of Streptomyces tenebrarius by Eli Lilly in 1967 as one of the eight components of the nebramycin complex. Apramycin is used in feed additives.

Chemical Properties

A yellow or yellow-brown powder, hygroscopic and easily soluble in water. Apramycin sulfate is an excellent drug for the prevention and treatment of bacterial diarrhea.

Uses

Apramycin sulfate has strong antibacterial activity against gram-negative bacteria and some gram-positive bacteria that are susceptible to infection in livestock and poultry, and can effectively prevent diarrhea caused by bacterial infection in livestock and poultry such as pigs, cattle and chickens , dysentery, dysplasia, etc..

Definition

ChEBI: Apramycin sulfate is a glycoside and an amino cyclitol.

Mechanism of action

Aapramycin sulfate can interfere with the synthesis of prokaryotic riboprotein to inhibit harmful bacteria in animals. It is an aminocycloalcohol antibiotic, which has strong antibacterial activity against Gram-negative bacteria and some Gram-positive bacteria that are susceptible to infection in livestock and poultry, especially Escherichia coli and Salmonella that are resistant to other antibiotics Other pathogenic bacteria have quite strong antibacterial effect, and it is not easy to develop drug resistance.