Trimebutine maleate is a white to off-white powder (M.P. 128˚C to 134˚C) very slightly soluble in ether and n-hexane, sparingly soluble in water, soluble in acetone, ethanol and methanol and freely soluble in chloroform.
Trimebutine maleate is an antispasmodic that functions as an opioid receptor agonist. Its mechanism of action involves regulating bowel movements and enhancing gastrointestinal function. Trimebutine is commonly used in the treatment of Irritable bowel syndrome. It is also used to restart the movement of the gut after abdominal surgery and to prevent intestinal blockage (paralytic ileus).
Possible side effects of trimebutine may include dry mouth, heartburn, nausea, diarrhea, constipation, drowsiness, dizziness, tiredness, indigestion, or headache. Other less frequent side effects are difficulty urinating, hearing loss, or painful breast enlargement. If any of these symptoms persist or worsen, please inform your doctor or pharmacist immediately.
