Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  API >  Specialty drugs >  Antidote >  Diethylenetriaminepentaacetic acid

Diethylenetriaminepentaacetic acid

Basic information Safety Related Supplier
Diethylenetriaminepentaacetic acid Basic information
Diethylenetriaminepentaacetic acid Chemical Properties
  • Melting point:219-220 °C(lit.)
  • Boiling point:517.84°C (rough estimate)
  • Density 1.56
  • refractive index 1.5700 (estimate)
  • Flash point:200 °C
  • storage temp. -20°C
  • solubility 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
  • pkapK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
  • form Crystalline Powder
  • color White to almost white
  • PH2-3 (H2O, 20℃)(saturated solution)
  • Water Solubility 5 g/L (20 ºC)
  • Merck 14,7125
  • BRN 1810219
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference67-43-6(CAS DataBase Reference)
  • NIST Chemistry ReferenceN,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6)
  • EPA Substance Registry SystemPentetic acid (67-43-6)
Safety Information
  • Hazard Codes Xi,N,Xn
  • Risk Statements 36-51/53-36/37/38-20-63
  • Safety Statements 26-36-61-37/39-36/37
  • RIDADR UN 3077 9/PG 3
  • WGK Germany 2
  • RTECS MB8205000
  • 3
  • TSCA Yes
  • HazardClass 9
  • PackingGroup III
  • HS Code 29224995
  • ToxicityLD50 orally in Rabbit: > 2000 mg/kg
Diethylenetriaminepentaacetic acid Usage And Synthesis
  • Chemical Propertiessolid
  • Chemical PropertiesPentetic acid occurs as a white crystalline solid and is almost odorless.
  • Chemical PropertiesDiethylenetriaminepentaacetic acid is a solid.
  • Useschelating agent, diagnostic aid
  • UsesDiethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.
  • Production MethodsPentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.
  • Pharmaceutical ApplicationsPentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.
  • Safety ProfileModerately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
  • SafetyPentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route.
    LD50 (mouse, IP): 0.54 g/kg
    LD50 (mouse, oral): 4.84 g/kg
  • storageThe activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
  • Purification MethodsCrystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]
  • IncompatibilitiesThe activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
  • Regulatory StatusIncluded in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.
Diethylenetriaminepentaacetic acid Preparation Products And Raw materials
Diethylenetriaminepentaacetic acid(67-43-6)Related Product Information
Diethylenetriaminepentaacetic acidSupplierMore
  • Company Name:Shanghai neon biological technology co., LTD Gold
  • Tel:021-54252912-8903
  • Company Name:Suqian nanxiang chemical manufacturing co. LTD Gold
  • Tel:13701755880 21-39125199-
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Tel:400-660-8290 21-61259100-
  • Company Name:future industrial shanghai co., ltd
  • Tel:400-0066-400