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Tulobuterol hydrochloride

Product NameTulobuterol hydrochloride
CAS56776-01-3
MFC12H19Cl2NO
MW264.19
EINECS634-677-4
MOL File56776-01-3.mol

Chemical Properties

Melting point	159-163℃
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White
Water Solubility	Soluble in methanol or water.
Sensitive	Hygroscopic
Merck	14,9811
Major Application	forensics and toxicology pharmaceutical (small molecule) veterinary
InChI	1S/C12H18ClNO.ClH/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13;/h4-7,11,14-15H,8H2,1-3H3;1H
InChIKey	RSLNRVYIRDVHLY-UHFFFAOYSA-N
SMILES	Cl.CC(C)(C)NCC(O)c1ccccc1Cl
CAS DataBase Reference	56776-01-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
RTECS	DN8785000
HS Code	2922.19.7000
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Usage And Synthesis

Uses

Hydrochloride salt of Tulobuterol a sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength. A β-adrenergic receptor agonist, related structurally to Terbutaline (T109750).

Uses

Tulobuterol hydrochloride (C-78) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol hydrochloride is also a sympathomimetic agent used as a transdermal patch, increases normal diaphragm muscle strength. Tulobuterol hydrochloride inhibit rhinovirus replication and modulate airway inflammation.

Definition

ChEBI: Tulobuterol hydrochloride is an organic molecular entity.

General Description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706019, T706030, T706020

in vivo

In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h^[3].

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