ChemicalBook Product Catalog Natural Products Flavonoids licoricidin

licoricidin

Product Namelicoricidin
CAS30508-27-1
MFC26H32O5
MW424.53
EINECS
MOL File30508-27-1.mol

Chemical Properties

Melting point	161.0-162.5℃
Boiling point	610.8±55.0 °C(Predicted)
Density	1.171±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	10.10±0.40(Predicted)
color	White to off-white
biological source	plant
Major Application	metabolomics vitamins, nutraceuticals, and natural products
InChI	1S/C26H32O5/c1-15(2)6-8-19-22(27)11-10-18(25(19)29)17-12-21-24(31-14-17)13-23(28)20(26(21)30-5)9-7-16(3)4/h6-7,10-11,13,17,27-29H,8-9,12,14H2,1-5H3/t17-/m0/s1
InChIKey	GBRZTUJCDFSIHM-KRWDZBQOSA-N
SMILES	O1C[C@H](Cc3c1cc(c(c3OC)CC=C(C)C)O)c2c(c(c(cc2)O)CC=C(C)C)O

Safety Information

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Usage And Synthesis

Uses

Licoricidin is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Definition

ChEBI: Licoricidin is a member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity. It has a role as an antibacterial agent and a plant metabolite. It is a member of hydroxyisoflavans, an aromatic ether and a methoxyisoflavan.

Biological Activity

Licoricidin (LCD), isolated from Glycyrrhiza uralensis Fisch, has anticancer activity. It (LCD) can be used in the study of colorectal cancer by inducing cycle arrest, apoptosis and autophagy. Licoricidin (LCD) inhibits lung metastasis by inhibiting tumor angiogenesis and lymphangiogenesis and changes in the local microenvironment of tumor tissue. Licoricidin (LCD) enhances gemcitabine-induced cytotoxicity of osteosarcoma (OS) cells through inactivation of Akt and NF-κB pathways in vitro and in vivo.

in vitro

Licoricidin (LCD) (0-20 μM; 24 hours) dose-dependently inhibits the viability of colon cancer cell lines with various pathological and genetic characters, namely SW480, HCT116, SW620 and LoVo cells, with IC < sub> 50 values of 7.2, 5.4, 4.5 and 5.1 μM, respectively. Licoricidin (LCD) (0-20 μM; 0-12 hours) induces cell apoptosis was accompanied with the activation of caspase-3 by cleavage in a time- and dose-dependent manner. Licoricidin (LCD) (0-20 μM; 0-12 hours) induces autophagy of SW480 cells, increases the cleavage of LC3-I to LC3-II and the degradation of p62 in a time and Dose dependent manner. Licoricidin (LCD) (0-5 μg/ml; 18 hours) inhibits cell migration, MMP-9 secretion, and VCAM expression in 4T1 cells.

< /p>

Cell Viability Assay

< tr>

Cell Line:	SW480, HCT116, SW620 and LoVo cells
Concentration:	0-20 μM
Incubation Time:	24 hours
Result:	Decreased colon cancer cell lines viability.

Western Blot Analysis < /p>

Cell Line:	SW480 cells
Concentration:	0 μM, 2.5 μM, 5 μM, 10 μM, 20 μM
Incubation Time:	0 hours, 1 hour, 3 hours, 6 hours, 12 hours
Result:	Induced cell apoptosis.

in vivo

Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 15 days) significantly inhibited the growth of SW480 xenografts in nude mice with an inhibitory rate of 43.5%. Licoricidin ( LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days) reduces pulmonary metastasis and the expression of CD45, CD31, HIF-1α, iNOS, COX-2, and VEGF-A in tumor tissues , additionally, decreased protein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 in tumor tissues of licoricidin-treated mice.

Animal Model:	SW480 xenografted tumor growth in nude mice
Dosage:	5, 10, or 20 mg/kg
Administration:	Intraperitoneal injection; once daily; 15 days
Result:	Decreased tumor volumes.

Animal Model:	BALB/c mouse orthotopic model
Dosage:	5, 10, or 20 mg/kg
Administration:	Intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days
Result:	Inhibited Lung Metastasis of 4T1 Murine Mammary Carcinoma cells.

licoricidin Supplier

licoricidin manufacturers

Related Product Information

Send Inquriy