Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor th at rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides th at are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported th at HCII and dermatan sulfate levels are elevated in pregnancy, suggesting th at HCII may be protective against thrombosis during pregnancy.', 'Serine protease th at inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.
