5-Nitrosalicylic acid

yellow powder

5-Nitrosalicylic Acid is a salicylic acid derivative with anti-inflammatory effect against colitis.

ChEBI: A monohydroxybenzoic acid in which the hydroxy group is ortho- to the carboxylic acid group and which has a nitro substituent para- to the phenolic hydroxy group.

Tetrahedron Letters, 36, p. 2377, 1995 DOI: 10.1016/0040-4039(95)00281-G

2-Hydroxy-5-nitrobenzoic acid inhibits the activity of wild type-bovine low M_r protein tyrosine phosphatase. The inhibition constant has been evaluated.

Non flammable

Crystallise the acid from Me2CO (charcoal), then twice more from Me2CO alone, aqueous EtOH (m 234-236o) or H2O (m 232-233o). [Beilstein 10 III 197, 10 IV 255.]