ChemicalBook > Product Catalog > API > Digestive system drugs > Antacid and Mucosal protective Drugs > Aluminium phosphate
Aluminium phosphate Chemical Properties
- Melting point:1500 °C
- Density 2.56 g/mL at 25 °C (lit.)
- storage temp. Inert atmosphere,Room Temperature
- solubility Very slightly soluble in water, practically insoluble in alcohol. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
- form Powder
- color White
- Specific Gravity2.566
- Water Solubility Insoluble
- Merck 14,358
- Solubility Product Constant (Ksp)pKsp: 20.01
- CAS DataBase Reference7784-30-7(CAS DataBase Reference)
- EPA Substance Registry SystemMonoaluminum phosphate (7784-30-7)
Aluminium phosphate Usage And Synthesis
- DescriptionAluminium phosphate occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaAl(PO4)(OH)]; augelite, [Al2(PO4)(OH)3]; lazulite, [(Mg,Fe)Al2(PO4)2(OH)2]; variscite [(Al,Fe3+)(PO4)•2H2O]; and wavellite, [Al3(OH)3•(PO4)2•5H2O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid.
- Chemical PropertiesWhite or almost white powder.
- Chemical PropertiesAluminum orthophosphate is a white crystalline solid which is often used in liquid or gel form
- Chemical PropertiesAluminum phosphate adjuvant is a white hydrogel that sediments slowly and forms a clear supernatant.
- Physical propertiesWhite powdery solid (rhombic plate); the mineral berlinite (AlPO4) has hexagonal quartz-like structure; refractive index 1.546; mp > 1,500°C; density 2.566 g/cu3; insoluble in water and alcohol; Ksp 9.83x10-10 very slightly soluble in HCl or HNO3.
- OccurrenceThe compound occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaAl(PO4)(OH)]; augelite, [Al2(PO4)(OH)3]; lazulite, [(Mg,Fe)Al2(PO4)2(OH)2]; variscite [(Al,Fe3+)(PO4)?2H2O]; and wavellite, [Al3(OH)3?(PO4)2?5H2O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid.
- UsesAntacid; vaccine adjuvant
- Production MethodsAluminum phosphate adjuvant is formed by the reaction of a solution of aluminum chloride and phosphoric acid with alkali hydroxide.
- PreparationIt is prepared by treating sodium aluminate with phosphoric acid.
- brand namePhosphaljel (Wyeth-Ayerst).
- General DescriptionA colorless liquid. Insoluble in water. Corrosive to metals and tissue.
- Air & Water ReactionsInsoluble in water.
- Reactivity ProfileAn acid. The resulting aqueous solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
- HazardSolutions are corrosive to tissue.
- Health HazardTOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
- Fire HazardNon-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
- Pharmaceutical ApplicationsAluminum phosphate adjuvant is used in parenteral human and veterinary vaccines.It activates Th2 immune responses, including IgG and IgE antibody responses.
- Safety ProfileCorrosive to the eyes, skin, and mucous membranes. When heated to decomposition it emits toxic fumes of POx. Used as an antacid and as a cement component, flux for ceramics, dental cement, glass, and gels. See also ALUMINUM COMPOUNDS and PHOSPHATES
- SafetyAluminum phosphate adjuvant is intended for use in parenteral vaccines and is generally regarded as safe. It may cause mild irritation, dryness, and dermatitis on skin contact. It may also cause redness, conjunctivitis, and short-term mild irritation on eye contact. Ingestion of large amounts of aluminum phosphate adjuvant may cause respiratory irritation with nausea, vomiting, and constipation. Inhalation is unlikely, although the dried product may cause respiratory irritation and cough. Type I hypersensitivity reactions following parenteral administration have also been reported.
- Potential ExposureUsed as a flux in ceramics; in dental cements; in the manufacture of special glasses, paints and varnishes, cosmetics; making pulp and paper; as an antacid.
- storageAluminum phosphate adjuvant is stable for at least 2 years when stored at 4–308℃ in well-sealed inert containers. It must not be allowed to freeze as the hydrated colloid structure will be irreversibly damaged.
- ShippingUN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required. UN3260 Corrosive solid, acidic, inorganic, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required.
- IncompatibilitiesThe point of zero charge is related directly to the Al : P atomic ratio. Therefore, the substitution of additional phosphate groups for hydroxyl groups will lower the point of zero charge. Substitution of carbonate, sulfate, or borate ions for hydroxyl groups will also lower the point of zero charge.
- IncompatibilitiesA strong oxidizer; keep away from combustible materials. Violent reaction with reducing agents; strong bases. Material is an inorganic acid and will react, possibly violently, with bases; corrosive to metals, some plastics and body tissues
- Regulatory StatusGRAS listed. Accepted for use in human and veterinary vaccines in Europe and the USA. The limits for use in human vaccines are 0.85 mg aluminum/dose (FDA) and 1.25 mg aluminum/dose (WHO). There are no established limits for use in veterinary vaccines. Reported in the EPA TSCA Inventory.
Aluminium phosphate Preparation Products And Raw materials
- ALUMINUM PHOSPHATE ANHYDROUS ALUMINUM PHOSPHATE,ALUMINUM PHOSPHATE TRIBASIC,ALUMINIUM PHOSPHATE BASIC,ALUMINIUM PHOSPHATE ALUMINUM PHOSPHATE HYDRATE, LIGHT Soduim aluminium hydrogen phosphate ALUMINUM PHOSPHATE, MONO ALUMINUM PHOSPHATE BASIC Sodium Aluminium Phosphate, Basic ammonium hexaamminecobalt(III) aluminum phosphate Sulfuric acid, aluminum salt (3:2), reaction products with aluminum hydroxide and aluminum phosphate (1:1) Sodium Aluminium Phosphate, Acidic ALUMINIUM PHOSPHATE HYDRATE tris(ethylenediamine)cobalt(III) aluminum phosphate SODIUM ALUMINUM PHOSPHATE ACIDIC CALCIUM ALUMINUM PHOSPHATE ALUMINUM PHOSPHATE, META triphosphate phosphate SODIUM ALUMINUM PHOSPHATE, ACIDIC,SODIUM ALUMINUM PHOSPHATE BASIC,Sodium aluminum phosphate,Sodium aluminium phosphate.acidic(SALP)
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